Portfolio companies

www.impulse-dynamics.com

Impulse Dynamics is a medical device company dedicated to offering innovative solutions for treatment of Chronic Heart Failure (CHF), based on its proprietary technology for administrating Cardiac Contractility Modulation (CCM) therapy. CCM has been shown in clinical trials to produce an immediate and powerful effect, resulting in a significant increase in cardiac performance, thereby improving exercise tolerance. Trials have also indicated its safety and its role in significantly improving quality of life. Impulse Dynamics’ Optimizer IVs is CE marked and has been successfully launched in Europe and other international markets. The device has been implanted in around 3,000 patients to date, with some receiving the therapy for over 10 years. The Optimizer IVs is currently undergoing the final stages of clinical evaluation to support FDA approval.

K2 Medical is developing an innovative dielectric imaging modality for structural heart disease that enables interventional cardiologists to image a variety of device implant procedures, using a standard disposable 3F multi electrode catheter.  K2 provides real time, 4 dimensional, high definition hybrid anatomical-functional images of the heart without the need of TEE and fluoroscopy.  K2 redefines interventional cardiac imaging by enabling interventional cardiologists full control of the imaging the procedure from access through validation, simplifying procedure logistics and improving overall procedure economics and outcomes.

RCS Technologies is facilitating remote clinical collaboration by offering a compact solution to remotely support interventional procedures in the Cath Lab and Operating Room while enabling high quality remote clinical education, proctoring, and industry support. This advanced technology platform allows hospitals to seamlessly collaborate with clinical partners and industry experts from any location, while ensuring the highest clinical data quality and maintaining patient privacy. The system is easy to install and includes advanced collaboration tools that provide an unparalleled user experience. RCS introduces a new dimension of clinical proctoring, education and industry support that significantly reduces the logistic requirements and costs associated with such activities. System integration involves only a minor addition of an RCS Immersion Box and its accessories to the Cath Lab/OR IT infrastructure.  Additionally, the RCS platform enables users to easily share and exchange knowledge on interventional procedures while monetizing on one’s experience through the RCS Network.

www.Motorika.com

Motorika develops and commercializes robot-assisted solutions to meet the therapeutic needs of patients suffering from variety of neurological conditions, including stroke, traumatic brain injury and spinal cord injury, as well as orthopedic and post-surgery dysfunction. Since its inception, the company has become established as a leader in the development and marketing of innovative, high-end, robotic rehabilitation products for the upper and lower extremities. Reo, the company’s flagship product family, actively engages patients’ neuromuscular re-education through intensive, repetitive, task-specific exercises in various robotic modes with instant augmented feedback. Reo improves upper and lower limb function, accelerates motor and cognitive recovery and provides improved clinical outcomes through a combination of a wide variety of movements and intense repetition. Motorika works with top experts in the field of Rehabilitation Medicine to develop high-level products that are flexible, easy-to-use and customized to each patient’s unique needs.

www.molecular-d.com

Molecular Dynamics develops innovative imaging technologies and advanced clinical applications. The company’s whole-body functional imaging system, based on CZT technology, simultaneously improves image quality, scan time and patient dose. The scanner delivers better-than-PET quality images, with an attractive wide-band, multi-function imaging ability not possible with current PET scanners. The company aims to enable improved diagnosis, treatment-optimization and monitoring, resulting in more cost-effective treatments and better clinical outcomes.

www.Renal-Dynamics.com

Renal Dynamics (ReDy) is dedicated to treating hypertension with a single intervention, using its third-generation renal denervation system. ReDy’s proprietary solution uses the SmartRF algorithm to optimize bipolar and unipolar energy delivery and to confirm lesion formation. The system uses an advanced product design, intended to improve usability by the operator, shorten procedure time and improve patient comfort. The ReDy system has obtained CE mark and is currently being validated in clinical trials.

OncoD is an early-stage company seeking to improve the treatment of cancer by simplifying image-guided solid-tumor ablation procedures. OncoD is currently developing a set of interventional radiology imaging tools which aim to improve clinical outcomes and shorten procedure time through hyper-reality visualization, real-time accurate monitoring of treatment effects and patient-specific pre-planning and procedure guidance. These will provide high-definition mapping and navigation capabilities outside of the imaging suite and without radiating computed tomography (CT) or expensive magnetic resonance imaging (MRI) devices. The optimized graphic user interface will lower the dependency on physician experience and shorten learning curves, making the procedure and its clinical benefits widely available for cancer patients globally.

Lavita Technologies is an early-stage neuromodulation company, focused on development of the proprietary Nexion™ system for treatment of autoimmune inflammatory diseases caused by an overactive sympathetic nervous system. This breakthrough technology has a wide range of applications, including rheumatoid arthritis, inflammatory bowel disease, and metabolic disorders. The Nexion™ system utilizes a catheter-based percutaneous approach to deliver targeted and localized energy to modulate and reset nerve activities specific to the inflammation.

Public and acquired companies

EPD Solutions, now a Philips Company, developed the KODEX – EPD™ cardiac mapping and navigation system which utilizes electromagnetic technology to create real-time three-dimensional, high definition (3D-HD) images of a patient’s cardiac structures. Due to its design, the KODEX – EPD™ cardiac mapping and navigation system enables the operator to use their preferred mapping and ablation catheters, rather than sensor based catheters.

A world leader in the development of robotic-assisted percutaneous interventions (PCIs), Corindus Vascular Robotics is the developer of the FDA-approved CorPath® System. CorPath’s unique technology and design provides interventional cardiologists with precision control in PCI procedures from within a cockpit, preventing exposure to radiation.
Exit: IPO

A developer and manufacturer of expandable orthopedic implants, Disc-O-Tech Medical Technologies offered products and systems to support minimally invasive surgery in the treatment of the spine, hip and trauma, including the B-Twin expandable spine spacer and the Fixion Hip System.
Exit: Merger

X-Technologies’ FXminiRAIL™ was developed for use in the treatment of coronary artery disease. Designed for the treatment of de novo lesions and in-stent restenosis, this unique device could also be employed in conjunction with stenting and brachytherapy.
Exit: Merger

Spectrum Dynamics’ innovative imaging systems are based on its pioneering Broadview™ technology. Through personalized molecular imaging and unique image quality and resolution, Spectrum Dynamics’ scanning technology and accessories aim to revolutionize the field of nuclear medicine.
Exit: Merger

NovoCure’s Tumor Treating Fields (TTFields) therapy is a pioneering treatment for solid tumors. Approved for use in adult patients with glioblastoma, the technology behind TTFields has the potential to provide a new line of therapy for a variety of cancers, alongside conventional surgery, radiation and chemotherapy.
Exit: IPO

Part of the Johnson & Johnson group of companies, and with a portfolio of products including the CARTO advanced imaging system, Biosense-Webster specializes in the science of diagnosing and treating cardiac arrhythmia. Working in partnership with clinical experts, the company is a world leader in the development of technologies in arrhythmia care.
Exit: Merger

InStent is was a developer and manufacturer of innovative stenting technology to support blood vessels and other passageways within the body. Producing both self-expandable and balloon stents, InStent’s products were based on a unique proprietary catheter delivery system.
Exit: Merger

Radiancy’s LHE™ (Light Heat Technology) and Thermicon™ technologies support a range of aesthetic and dermatological devices for both professional and home use. As a leading developer and manufacturer in the field of dermatology, Radiancy’s professional products offer treatment for acne, skin tightening, psoriasis and hair removal.
Exit: Merger

EPD Solutions, now a Philips Company, developed the KODEX – EPD™ cardiac mapping and navigation system which utilizes electromagnetic technology to create real-time three-dimensional, high definition (3D-HD) images of a patient’s cardiac structures. Due to its design, the KODEX – EPD™ cardiac mapping and navigation system enables the operator to use their preferred mapping and ablation catheters, rather than sensor based catheters.

NovoCure’s Tumor Treating Fields (TTFields) therapy is a pioneering treatment for solid tumors. Approved for use in adult patients with glioblastoma, the technology behind TTFields has the potential to provide a new line of therapy for a variety of cancers, alongside conventional surgery, radiation and chemotherapy.
Exit: IPO

A world leader in the development of robotic-assisted percutaneous interventions (PCIs), Corindus Vascular Robotics is the developer of the FDA-approved CorPath® System. CorPath’s unique technology and design provides interventional cardiologists with precision control in PCI procedures from within a cockpit, preventing exposure to radiation.
Exit: IPO

Part of the Johnson & Johnson group of companies, and with a portfolio of products including the CARTO advanced imaging system, Biosense-Webster specializes in the science of diagnosing and treating cardiac arrhythmia. Working in partnership with clinical experts, the company is a world leader in the development of technologies in arrhythmia care.
Exit: Merger

A developer and manufacturer of expandable orthopedic implants, Disc-O-Tech Medical Technologies offered products and systems to support minimally invasive surgery in the treatment of the spine, hip and trauma, including the B-Twin expandable spine spacer and the Fixion Hip System.
Exit: Merger

InStent is was a developer and manufacturer of innovative stenting technology to support blood vessels and other passageways within the body. Producing both self-expandable and balloon stents, InStent’s products were based on a unique proprietary catheter delivery system.
Exit: Merger

X-Technologies’ FXminiRAIL™ was developed for use in the treatment of coronary artery disease. Designed for the treatment of de novo lesions and in-stent restenosis, this unique device could also be employed in conjunction with stenting and brachytherapy.
Exit: Merger

Radiancy’s LHE™ (Light Heat Technology) and Thermicon™ technologies support a range of aesthetic and dermatological devices for both professional and home use. As a leading developer and manufacturer in the field of dermatology, Radiancy’s professional products offer treatment for acne, skin tightening, psoriasis and hair removal.
Exit: Merger

Spectrum Dynamics’ innovative imaging systems are based on its pioneering Broadview™ technology. Through personalized molecular imaging and unique image quality and resolution, Spectrum Dynamics’ scanning technology and accessories aim to revolutionize the field of nuclear medicine.
Exit: Merger

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